CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.
CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.
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DOI：
10.1136/jclinpath-2014-202735
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Tan PH
中科院分区：
文献类型：
--
作者：
Chong TW;Goh FY;Sim MY;Huang HH;Thike AA;Lim WK;Teh BT;Tan PH
我们假设，CD 1d在肾细胞癌（RCC）的表达可能在修改宿主免疫反应中发挥作用。我们的目的是研究CD 1d的表达，并将其与RCC患者的组织病理学和临床结局进行队列研究。对一组RCC组织进行基因表达和组织微阵列研究。采用χ2/Fisher精确检验分析临床病理相关性。计算CD 1d高表达和低表达者的无复发生存期、癌症特异性生存期和总生存期。采用Kaplan-Meier法估计生存结局，并采用考克斯回归分析进行比较。基因表达谱芯片显示，肾癌组织中CD 1d的表达显著高于正常肾组织。通过免疫组化，我们发现CD 1d表达与肿瘤分期/分级、较高的复发率、较差的癌症特异性和总生存率显著相关。肾细胞癌CD 1d表达与肿瘤的侵袭性和临床预后相关。
We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ2/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan–Meier method and compared using Cox regression analysis. Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival. CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.
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影响因子：
2.1
作者：
SNOW, RM;SCHELLHAMMER, PF
通讯作者：
SCHELLHAMMER, PF
影响因子：
4.3
作者：
Kawasaki, Yoshihide;Ito, Akihiro;Arai, Yoichi
通讯作者：
Arai, Yoichi
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
6.4
作者：
Dhodapkar, KM;Cirignano, B;Steinman, RM
通讯作者：
Steinman, RM
B7-H3的肿瘤细胞和肿瘤脉管表达预测透明细胞肾细胞癌的存活。
DOI：
10.1158/1078-0432.ccr-08-0536
发表时间：
2008-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Crispen PL;Sheinin Y;Roth TJ;Lohse CM;Kuntz SM;Frigola X;Thompson RH;Boorjian SA;Dong H;Leibovich BC;Blute ML;Kwon ED
通讯作者：
Kwon ED