Reconsideration of the role of fibronectin binding in endocarditis caused by Staphylococcus aureus
Reconsideration of the role of fibronectin binding in endocarditis caused by Staphylococcus aureus
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DOI：
10.1128/iai.64.5.1876-1878.1996
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发表时间：
1996-05-01
影响因子：
3.1
通讯作者：
Schennings, T
中科院分区：
文献类型：
--
作者：
Flock, JI;Hienz, SA;Schennings, T
在导管诱导的感染性心内膜炎大鼠模型上，比较了两株纤维连接蛋白结合不同的金黄色葡萄球菌的体内黏附特性和毒力。这两个菌株之间没有发现差异。这些结果有力地指出了细菌与受损心脏瓣膜黏附的多因素性质，并表明其他结合功能可以弥补金黄色葡萄球菌中纤维连接蛋白结合的缺乏。
The adherence characteristics in vivo and virulence of two isogenic strains of Staphylococcus aureus differing in fibronectin binding were compared in a rat model of catheter-induced infective endocarditis. No differences were found between the two strains. The results strongly point to the multifactorial nature of bacterial adherence to damaged heart valves and suggest that other binding functions can compensate for the lack of fibronectin binding in S. aureus.