Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: Prevalence, clinical associations and correlation with other autoantibodies
Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: Prevalence, clinical associations and correlation with other autoantibodies
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发表时间：
1998-09
影响因子：
3.7
通讯作者：
M. Galeazzi;G. Morozzi;G. Sebastiani;E. Bellisai;R. Marcolongo;R. Cervera;E. Garrido;A. Fernández-Nebro;E. Houssiau;A. Jędryka-Góral;A. Mathieu;C. Papasteriades;J. Piette;R. Scorza;J. Smolen
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作者：
M. Galeazzi;G. Morozzi;G. Sebastiani;E. Bellisai;R. Marcolongo;R. Cervera;E. Garrido;A. Fernández-Nebro;E. Houssiau;A. Jędryka-Góral;A. Mathieu;C. Papasteriades;J. Piette;R. Scorza;J. Smolen
在一项来自11个欧洲中心的566例系统性红斑狼疮（SLE）患者队列研究中，评估：(i)大量欧洲SLE患者中anca的患病率及其亚特异性；（II） ANCA与该疾病最常见临床表现的可能关联；（iii） anca是否与SLE中常见的一些自身抗体相关。方法采用间接免疫荧光法（IIF）和酶联免疫吸附法（ELISA）检测NCA的乳铁蛋白（LF）、髓过氧化物酶（MPO）、蛋白酶3 （PR3）和溶菌酶（LZ）亚特异性。结果ANCA患病率为16.4% （IIF）。LF患病率14.3%，LZ患病率4.6%，MPO患病率9.3%，PR3患病率1.7%。我们的研究结果表明，ANCA与SLE的某些临床表现有关。特别是，IIF - ANCA与血清炎（p = 0.026）、网状脂肪肝（p = 0.01）、静脉血栓形成（p = 0.03）和关节炎（p = 0.04）呈正相关，而抗lf抗体与血清炎（p = 0.05）和网状脂肪肝（p < 10(-3)）相关。然而，多变量分析表明，其他自身抗体，如aCL和SSA/Ro，与上述一些临床特征的相关性比ANCA更密切。结论在SLE血清中可以检测到ANCA，其中一些与特定的临床表现有关。ANCA是否在SLE的血管损伤中起直接的致病作用，还是仅仅代表一种附带现象或疾病活动的标志，仍有待阐明。
Objectives To evaluate, in a cohort of 566 patients with systemic lupus erythematosus (SLE) drawn from 11 European centres: (i) the prevalence of ANCAs and their subspecificities in a large series of European SLE patients; (II) the possible associations of ANCA with the most common clinical manifestations of the disease; and (iii) whether ANCAs correlate with some of the autoantibodies commonly found in SLE. Methods NCA detection was performed by indirect immunofluorescence (IIF), and by ELISA for lactoferrin (LF), myeloperoxydase (MPO), proteinase3 (PR3) and lysozyme (LZ) subspecificities. Results The prevalence of ANCA was 16.4% (IIF). The prevalence of LF was 14.3%, LZ 4.6%, MPO 9.3%, and PR3 1.7%. Our results show that ANCA is associated with certain clinical manifestations of SLE. In particular, positive correlations were found between IIF ANCA and serositis (p = 0.026), livedo reticularis (p = 0.01), venous thrombosis (p = 0.03) and arthritis (p = 0.04), while anti-LF antibodies were associated with serositis (p = 0.05) and livedo reticularis (p < 10(-3)). Nevertheless, multivariate analysis demonstrated that other autoantibodies, such as aCL and SSA/Ro, are more closely correlated than ANCA with some of the aforementioned clinical features. Conclusion Our results demonstrate that ANCA are detectable in SLE sera and that some of them are associated with particular clinical manifestations. Whether ANCA plays a direct pathogenetic role in the vascular damage of SLE or only represents an epiphenomenon or a marker of disease activity remains to be elucidated.