Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
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DOI：
10.1016/j.neuroscience.2007.10.054
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发表时间：
2008-02-06
期刊：
影响因子：
3.3
通讯作者：
Ashe, K. H.
中科院分区：
文献类型：
--
作者：
Lesne, S.;Kotilinek, L.;Ashe, K. H.
淀粉样蛋白β（A β）蛋白以不同的组装状态存在于衰老的哺乳动物大脑中，包括淀粉样蛋白斑和可溶性A β寡聚体。这两种形式的A β已被证明会损害神经元功能，但它们在阿尔茨海默病（AD）相关记忆丧失中的确切作用仍不清楚。这两种类型的A β通常同时存在于大脑中，这使得很难单独评估斑块和寡聚体对记忆功能的影响。最近，一种特殊的寡聚A β组装体A β *56被发现在没有淀粉样斑块的情况下损害记忆功能。到目前为止，还不可能确定在缺乏A β寡聚体的情况下斑块对记忆功能的影响。我们已经确定了Tg2576小鼠与斑块，但显着降低水平的A β油，这使我们能够研究斑块单独对记忆功能的影响。我们发现，淀粉样斑块的动物在整个A β低聚物减少的过程中具有正常的记忆功能，这发生在淀粉样斑块形成加速的时期。这些观察结果支持了A β寡聚体在记忆丧失中的重要性，并表明至少在最初，淀粉样蛋白斑块不会损害记忆。(c)2007年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The amyloid-beta (A beta) protein exists in the aging mammalian brain in diverse assembly states, including amy[old plaques and soluble A beta oligomers. Both forms of A beta have been shown to impair neuronal function, but their precise roles in Alzheimer's disease (AD) -associated memory loss remain unclear. Both types of A beta are usually present at the same time in the brain, which has made it difficult to evaluate the effects of plaques and oligomers individually on memory function. Recently, a particular oligomeric A beta assembly, A beta*56, was found to impair memory function in the absence of amyloid plaques. Until now it has not been possible to determine the effects of plaques, in the absence of A beta oligomers, on memory function. We have identified Tg2576 mice with plaques but markedly reduced levels of A beta oilgomers, which enabled us to study the effects of plaques alone on memory function. We found that animals with amyloid plaques have normal memory function throughout an episode of reduced A beta oligomers, which occurs during a period of accelerated amyloid plaque formation. These observations support the importance of A beta oligomers in memory loss and indicate that, at least initially, amyloid plaques do not impair memory. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.