CHROMOSOMAL MAPPING IN THE MOUSE OF 8 K+-CHANNEL GENES REPRESENTING THE 4 SHAKER-LIKE SUBFAMILIES SHAKER, SHAB, SHAW, AND SHAL
CHROMOSOMAL MAPPING IN THE MOUSE OF 8 K+-CHANNEL GENES REPRESENTING THE 4 SHAKER-LIKE SUBFAMILIES SHAKER, SHAB, SHAW, AND SHAL
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DOI：
10.1016/s0888-7543(05)80358-1
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发表时间：
1993-12-01
期刊：
影响因子：
4.4
通讯作者：
JOCKUSCH, H
中科院分区：
文献类型：
--
作者：
KLOCKE, R;ROBERDS, SL;JOCKUSCH, H
哺乳动物中的Shaker-、Shab-、Shaw-和Shal-相关的K+通道的四个Shaker样亚家族已根据它们与相应果蝇基因的序列同源性而被定义。使用种间回交小家鼠和小家鼠spretus，我们已经在小鼠染色体定位的Shaker相关的K+通道基因Kcna 1，Kcna 2，Kcna 4，Kcna 5，和Kcna 6; Shab相关基因Kcnb 1; Shaw相关基因Kcnc 4;和Shal相关基因Kcnd 2。Chr 2、cen-Acra-Kcna 4-Pax-6-a-Pck-1-Kras-3-Kcnb 1（分别对应于人Chrs 11 p和20 q）; Chr 3，cen-Hao-2-（Kcna2，Kcnc4）-Amy-1（人Chr 1）;和Chr 6，cen-Cola-2-Met-Kcnd 2-Cpa-Tcrb-adr/Clc-1-Hox-1.1-Myk-103-Raf-1-（Tpi-1，Kcna 1，Kcna 5，Kcna 6）（分别为人Chrs 7 q和12 p）。因此，在小鼠Chr 6远端存在一个至少由3个Shaker相关的K+通道基因组成的基因簇，而在Chr 2远端存在一个至少由1个Shaker相关基因和1个Shaw相关基因组成的基因簇。其他三个K+通道基因彼此不相关。不同类型的K+-通道基因在小鼠中的地图位置进行了讨论，在人类和小鼠和人的遗传性疾病，可能涉及K+通道的同源物。
The fourShaker-like subfamilies ofShaker-, Shab-,Shaw-, andShal-related K+channels in mammals have been defined on the basis of their sequence homologies to the correspondingDrosophilagenes. Using interspecific backcrosses betweenMus musculusandMus spretus, we have chromosomally mapped in the mouse theShaker-related K+-channel genesKcna1, Kcna2, Kcna4, Kcna5, andKcna6; theShab-related geneKcnb1; theShaw-related geneKcnc4; and theShal-related geneKcnd2. The following localizations were determined: Chr 2, cen-Acra-Kcna4-Pax-6-a-Pck-1-Kras-3-Kcnb1(corresponding human Chrs 11p and 20q, respectively); Chr 3, cen-Hao-2-(Kcna2, Kcnc4)-Amy-1(human Chr 1); and Chr 6, cen-Cola-2-Met-Kcnd2-Cpa-Tcrb-adr/Clc-1-Hox-1.1-Myk-103-Raf-1-(Tpi-1, Kcna1, Kcna5, Kcna6) (human Chrs 7q and 12p, respectively). Thus, there is a cluster of at least threeShaker-related K+-channel genes on distal mouse Chr 6 and a cluster on Chr 2 that at least consists of oneShaker-related and oneShaw-related gene. The three other K+-channel genes are not linked to each other. The map positions of the different types of K+-channel genes in the mouse are discussed in relation to those of their homologs in man and to hereditary diseases of mouse and man that might involve K+channels.