Relationship between difficulty in performing daily activities and clinical measures of visual function in patients with retinitis pigmentosa
Relationship between difficulty in performing daily activities and clinical measures of visual function in patients with retinitis pigmentosa
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DOI：
10.1001/archopht.1997.01100150055009
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发表时间：
1997-01-01
影响因子：
--
通讯作者：
Anderson, RJ
中科院分区：
文献类型：
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作者：
Szlyk, JP;Fishman, GA;Anderson, RJ
目的：评估视网膜色素变性(RP)患者在日常活动中感受到的困难程度，并确定患者自我报告的困难程度与临床视功能指标之间的相关性。方法：167例典型的RP和Usher综合征患者，疾病严重程度广泛，在33项活动中对他们的操作困难进行评估。我们获得了所有患者的视力和视野面积的数据，以及其中49名患者的视网膜电图(ERG)记录。对问卷调查结果进行因素分析，并将患者的自我报告与临床资料进行相关分析和多元回归分析。结果：患者的问卷调查分为6个因素：涉及中心视力的活动、其他活动(无明显共同因素)、与活动有关的活动、驾驶、谈判步骤和进餐。在临床测试中，视力与患者对操作困难的评分关系最密切。视野面积也与患者的自我评估有关，但不像视力那么强。由于视野面积与ERG测量相关，加入ERG信息并不能提高预测性。结论：在RP患者中，执行普通任务的知觉困难与视力水平和视野密切相关。虽然某些ERG波幅测量确实与一些自我报告的活动呈正相关，但总体而言，ERG波幅测量与患者的自我报告的关系最小。我们的结果提供了对RP患者在日常活动中感觉到的困难的洞察，以及与这些困难高度相关的视觉功能的临床测量。
Objectives: To assess the level of perceived difficulty experienced by patients with retinitis pigmentosa (RP) in the performance of everyday activities and to determine the correlation between patients' self-reported difficulty and clinical measures of visual function.Methods: One hundred sixty-seven patients with typical RP and Usher syndrome type 2, with a wide range of disease severity, rated their difficulty in the performance-of 33 activities. We obtained data on visual acuity and visual field area for all patients, and electroretinogram (ERG) recordings on a subgroup of 49 of these patients. Results from the questionnaire were analyzed with factor analysis, and patients' self-reports were compared with their clinical data using correlational analyses and multiple regression.Results: The patients' questionnaire responses clustered into 6 factors: activities involving central vision, miscellaneous activities (no discernible common factor), activities related to mobility, driving, negotiating steps, and eating meals. Of the clinical tests, visual acuity was most strongly related to the patients' ratings of their difficulty in performance. Visual field area also was related to patients' self-assessments but not as strongly as visual acuity. Because visual field area and the ERG measures were correlated, adding ERG information did not improve predictability.Conclusions: In patients with RP, perceived difficulty in performing common tasks was most strongly related to level of visual acuity and visual fields. Although certain ERG amplitude measures did show positive correlations with some self-reported activities, overall, the ERG amplitude measures showed the least relationship with patients' self-reports. Our results provide insight into RP patients' perceived difficulties in performing everyday activities and the clinical measures of visual function that most highly correlate with these difficulties.