Monoolein: a magic lipid?
Monoolein: a magic lipid?
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DOI：
10.1039/c0cp01539c
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Ahualli, Silvia
中科院分区：
文献类型：
--
作者：
Kulkarni, Chandrashekhar V.;Wachter, Wolfgang;Ahualli, Silvia
在过去的几年中，描述油酸甘油酯多种应用的出版物急剧增加，油酸甘油酯是药物输送、乳液稳定和蛋白质结晶领域最重要的脂质之一。从这个角度来看，我们对这种“神奇脂质”的相行为进行了全面的回顾。提供了在水存在下形成的各种中间相的说明以及用于计算其纳米结构参数的公式的集合。还讨论了化学和生物分子（包括脂质、去污剂、盐、糖、蛋白质和 DNA）对经典行为的影响。物理化学触发因素（例如温度、压力和剪切）调节单油酸甘油酯自组装的相行为，这将在后续部分中介绍。最后还报道了单油酸甘油酯在各个领域的日益增长的应用。
During the last few years, there has been an extraordinary increase in publications describing the manifold applications of monoolein, one of the most important lipids in the fields of drug delivery, emulsion stabilization and protein crystallization. In this perspective we present a comprehensive review of the phase behavior of this 'magic lipid'. An account of various mesophases formed in the presence of water and a collection of formulae for the calculation of their nano-structural parameters are provided. Effects of chemical and biological molecules including lipids, detergents, salts, sugars, proteins and DNA on the classical behavior are also discussed. Physicochemical triggers such as, temperature, pressure and shearing modulate the phase behavior of monoolein self assemblies that are covered in subsequent sections. Finally the growing applications of monoolein in various fields are also reported.