Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy
Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy
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DOI：
10.1007/s00401-005-1064-y
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发表时间：
2005-09-01
影响因子：
12.7
通讯作者：
Lintner, F
中科院分区：
文献类型：
--
作者：
Attems, J;Jellinger, KA;Lintner, F
脑淀粉样血管病（CAA）是由脑血管中的β-淀粉样肽（A β）沉积定义的，并且与阿尔茨海默病（AD）相关。散发性CAA和AD之间的关系以及CAA中A β的起源知之甚少。本研究旨在探讨CAA与AD的关系。尸检脑（n=113，61.1%女性，55.8%临床痴呆，年龄范围54-102岁，平均+/- SE 83.5 +/- 0.93岁）进行标准化神经病理学评估。CAA在额叶、额基底、海马和枕区进行评价。使用免疫组织化学，分别对每个区域的血管中A β沉积的严重程度进行半定量评估。实时荧光定量PCR检测53例AD患者的APOE基因型，结果显示，APOE基因型与重度AD病理和CAA有显著相关性。CAA共77例（68.1%），枕部受累明显多于其他部位（P
Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (A beta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD). The relationship between sporadic CAA and AD, and the origin of A beta in CAA are poorly understood. The aim of our study was to investigate the relationship between CAA and AD. Autopsy brains (n=113, 61.1% female, 55.8% clinically demented, age range 54-102 years, mean +/- SE 83.5 +/- 0.93 years) underwent standardized neuropathological assessment. CAA was evaluated in frontal, frontobasal, hippocampal, and occipital regions. Using immunohistochemistry, the severity of A beta deposition in vessels was assessed semiquantitatively for each region separately. Evaluation of APOE genotype in 53 cases using real-time PCR showed significant correlations with severe AD pathology and CAA. CAA was present in 77 cases (68.1%), with the occipital region being affected significantly more often and more severely than other regions (P