Ferrocene-peptide bioconjugates
Ferrocene-peptide bioconjugates
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DOI：
10.1007/3418_005
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Hirao, Toshikazu
中科院分区：
文献类型：
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作者：
Moriuchi, Toshiyuki;Hirao, Toshikazu
本章概述了二茂铁-多肽生物偶联物的概况。人们设计了多种二茂铁-多肽生物偶联物来诱导多肽的高度有序结构，并开发新的生物材料。二茂铁是一种非常可靠的有机金属支架，通过分子内氢键构建有序结构，其中连接的多肽链在适当的维度上受到调节。二茂铁-多肽生物偶联物的另一个值得注意的特征是它们通过固体中可用的氢键位置的贡献而强烈地自组装。此外，二茂铁-多肽生物结合物中的二茂铁部分能够在受体和生物材料中作为氧化还原开关中心和电泳体。
This chapter sketches an outline of ferrocene–peptide bioconjugates. A variety of ferrocene–peptide bioconjugates have been designed to induce highly ordered structures of peptides and develop new biomaterials. The ferrocene serves as a reliable organometallic scaffold for the construction of an ordered structure via intramolecular hydrogen bonding, wherein the attached peptide strands are regulated in appropriate dimensions. Another noteworthy feature of ferrocene–peptide bioconjugates is their strong tendency to self-assemble through the contribution of available hydrogen bonding sites in the solid state. Furthermore, the ferrocene moiety of ferrocene–peptide bioconjugates is able to act as a redox-switching center and an electrophore in the receptors and biomaterials.