Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas
Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas
复制标题
DOI：
10.1002/jso.20766
复制
发表时间：
2008-01-01
影响因子：
2.5
通讯作者：
Tsuneyoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Itakura, Eijun;Yamamoto, Hidetaka;Tsuneyoshi, Masazumi
背景资料：血管肉瘤是恶性间叶肿瘤，包括假定血管内皮来源的肉瘤和可能的淋巴来源的肉瘤。然而，通常很难确定它们是来自血管内皮还是淋巴内皮。大多数血管内皮细胞瘤被认为起源于血管内皮细胞并通过血流扩散到肺，但也可发生淋巴转移。（VEGF-A、VEGF-C）及其受体VEGFR-1、VEGFR-2、VEGFR-3在34例血管瘤中的表达。VEGF-A表达32/34（94%），VEGF-C表达4/34（12%），VEGFR-1表达32/34（94%），VEGFR-2表达22/34（65%），VEGFR-3表达27/34（79%）。对数秩检验（P=0.010）和多变量分析（风险比，5.16; 95%CI，1.40-19.04; P=0.014）显示，VEGFR-2低表达或无表达的患者预后显著不良。结论：VEGF-A和VEGFR-1在不同亚型的血管瘤中均有表达。VEGF-A和VEGF-C可能共同参与了与水肿相关的血管肉瘤的发生。VEGF-C表达可能通过肿瘤淋巴管生成引起淋巴转移的易感性。头皮的血管肉瘤，传统上被认为是真正的血管肉瘤，可能包括一些淋巴起源的病例。
Background: Angiosarcomas are malignant mesenchymal neoplasms, including sarcomas of presumptive vascular endothelial origin and sarcomas of probable lymphatic origin. It is, however, often difficult to determine whether they are from blood vascular or lymphatic endothelium. The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur.Methods: We investigated immunohistochemical expression of vascular endothelial growth factors (VEGF-A, VEGF-C) and their receptors (VEGFR-1, VEGFR-2, VEGFR-3) in a series of 34 angiosarcomas.Results: VEGF-A was expressed by 32/34 (94%), VEGF-C by 4/34 (12%), VEGFR-1 by 32/34 (94%), VEGFR-2 by 22/34 (65%), and VEGFR-3 by 27/34 (79%). Patients who expressed low or no VEGFR-2 showed a significantly unfavorable prognosis by log-rank test (P=0.010) and multivariate analysis (hazard ratio, 5.16; 95% CI, 1.40-19.04; P=0.014). VEGFR-1 and VEGFR-3 were not significantly associated with patients' prognosis.Conclusions: VEGF-A and VEGFR-1 were detected in diverse subtypes of angiosarcomas. In cooperation, VEGF-A and VEGF-C are likely to be involved in the development of angiosarcoma associated with lymphedema. VEGF-C expression may cause susceptibility to lymphatic metastasis through tumor lymphangiogenesis. Angiosarcoma of the scalp, which is traditionally considered as a true hemangiosarcoma, may include some cases of lymphatic origin.