Chronic foot shock induces hyperactive behaviors and accompanying pro- and anti-inflammatory responses in mice
Chronic foot shock induces hyperactive behaviors and accompanying pro- and anti-inflammatory responses in mice
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DOI：
10.1016/j.jneuroim.2007.03.003
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Moynihan, Jan A.
中科院分区：
文献类型：
--
作者：
Cao, Ling;Hudson, Chad A.;Moynihan, Jan A.
本文研究了成年雄性BALB/c小鼠慢性不规则轻度足电击（CMFS）过程中不同时间的行为学及伴随的生理和免疫学变化。CMFS在熟悉的环境中诱导了显着的hyperomotor活动，以及在整个5周的压力期间增加巧克力牛奶（一种受欢迎的饮料）的消费。与其他慢性应激模型不同，CMFS没有诱导抑郁样行为。活动过度与促炎细胞因子（TNF α和IL-1 β）和IL-2的一过性升高以及脾脏中抗炎介质的更持续（IL-10）或更晚（IL-10活性）升高相关（血清水平低于检测水平），表明CMFS期间从促炎状态转变为抗炎状态。还检测到IL-2和α-淀粉酶活性的脑水平的类似增加，并且可能有助于CMFS诱导的多动症，因为这两种介质都已显示出诱导多动症。据我们所知，这是第一次在压力范例中记录到增加的脱氢酶活性。总之，这些数据表明，CMFS诱导的行为变化不同于其他慢性应激模型。CMFS与多种动态免疫学变化相关，提示慢性应激诱导的行为改变涉及多种因素。(c)2007 Elsevier B. V.保留所有权利。
Behavioral and accompanying physiological and immunological changes were investigated at various times during chronic irregular mild foot shock (CMFS) in adult male BALB/c mice. CMFS induced a significant hyperlocomotor activity in a familiar environment as well as increased consumption of chocolate milk (a favored drink) throughout the 5-week stress period. Unlike other chronic stress models, CMFS did not induce depressive-like behaviors. Hyperactivity was associated with transient elevations of pro-inflammatory cytokines (TNF alpha and IL-1 beta) and IL-2 and more sustained (IL-10) or later (arginase activity) elevations in anti-inflammatory mediators in the spleen (serum levels below levels of detection) suggesting a transition from a pro-inflammatory state to an anti-inflammatory state during CMFS. Similar increases in brain levels of IL-2 and arginase activity were also detected and may contribute to CMFS-induced hyperactivity as both of these mediators have been shown to induce hyperactivity. To our knowledge, this is the first time that increased arginase activity has been documented during a stress paradigm. Altogether, the data indicate that CMFS induces behavioral changes distinct from other chronic stress models. CMFS is associated with multiple dynamic immunological changes, suggesting involvement of multiple factors in chronic stress-induced behavioral changes. (c) 2007 Elsevier B.V. All rights reserved.