Psychoneuroimmunology: psychological influences on immune function and health.
Psychoneuroimmunology: psychological influences on immune function and health.
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DOI：
10.1037/0022-006x.70.3.537
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发表时间：
2002-06
影响因子：
5.9
通讯作者：
J. Kiecolt-Glaser;L. Mcguire;T. Robles;R. Glaser
中科院分区：
文献类型：
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作者：
J. Kiecolt-Glaser;L. Mcguire;T. Robles;R. Glaser
本文综述了近十年来有关人类心理神经免疫学的研究进展。讨论的问题包括通过心理因素影响免疫功能的途径，如何应激源的持续时间可能会影响观察到的变化，个体差异变量，干预措施调节免疫功能的能力，以及社会心理介导的免疫失调的健康后果。强调了负面影响和支持性个人关系的重要性。最近的数据表明，免疫失调可能是一系列与衰老相关的疾病的核心机制，包括心血管疾病，骨质疏松症，关节炎，2型糖尿病，某些癌症以及虚弱和功能衰退;影响这些和其他疾病的促炎细胞因子的产生可以直接由负面情绪刺激，间接由长期感染刺激。
This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability of interventions to modulate immune function, and the health consequences of psychosocially mediated immune dysregulation. The importance of negative affect and supportive personal relationships are highlighted. Recent data suggest that immune dysregulation may be one core mechanism for a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, Type 2 diabetes, certain cancers, and frailty and functional decline; production of proinflammatory cytokines that influence these and other conditions can be stimulated directly by negative emotions and indirectly by prolonged infection.