Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
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DOI：
10.1002/art.34526
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发表时间：
2012-05
影响因子：
--
通讯作者：
Lane, Nancy E
中科院分区：
文献类型：
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作者：
Baker-Lepain, Julie C;Lynch, John A;Parimi, Neeta;McCulloch, Charles E;Nevitt, Michael C;Corr, Maripat;Lane, Nancy E
(1)目的：探讨FRZB基因单核苷酸多态性（SNPs）与髋部形态的关系。(2)研究FRZB变异等位基因是否影响髋关节形态与放射学髋关节骨关节炎（RHOA）的关系。在骨质疏松性骨折研究（SOF）中，对年龄≥ 65岁的白人女性进行了一项巢式病例对照研究。451例病例在随访期间（平均8.0 ± 0.4年）证实了RHOA事件。对照组（n = 601）在基线或随访时无RHOA。数字化髋关节X线片的统计形状建模（SSM）用于评估股骨近端形状，中心边缘角和髋臼深度用于评估髋臼形状。使用线性回归分析rs 288326和rs7775 FRZB变异等位基因与髋关节形状的关联。这些等位基因对髋部形状和RHOA之间的关系的影响进行了分析，使用逻辑回归和无交互作用的条款。rs 288326和rs7775等位基因与股骨近端的形状相关（SSM模式2）。rs 288326 SNP和股骨近端形状（模式2）在预测RHOA方面存在显著的相互作用（相互作用p = 0.022）。在具有rs 288326变异等位基因的受试者中，随着股骨近端形状模式2的四分位数增加，RHOA的几率增加（模式2的第四个四分位数的OR = 2.5，95%置信区间1.2-5.3;线性趋势p = 0.02）。rs 288326和rs7775 FRZB SNP与股骨近端的形状相关。rs 288326 SNP的存在改变了股骨近端形状与RHOA事件之间的关系。总之，这些研究结果表明，FRZB可能在确定髋关节形状中起重要作用，并可能改变髋关节形状和OA之间的关系。
(1) To test whether single nucleotide polymorphisms (SNPs) of the FRZB gene are associated with hip shape. (2) To determine whether FRZB variant alleles affect the relationship between hip shape and radiographic hip osteoarthritis (RHOA). A nested case-control study of Caucasian women aged ≥ 65 years in the Study of Osteoporotic Fractures (SOF) was performed. Cases (n = 451) demonstrated incident RHOA during follow-up (mean 8.0 ± 0.4 years). Controls (n = 601) had no RHOA at baseline or follow-up. Statistical shape modeling (SSM) of digitized hip radiographs was used to assess proximal femur shape, and center-edge angle and acetabular depth were used to assess acetabular shape. The association of the rs288326 and rs7775 FRZB variant alleles with hip shape was analyzed using linear regression. The effect of these alleles on the relationship between hip shape and RHOA was analyzed using logistic regression with and without interaction terms. The rs288326 and rs7775 alleles were associated with shape of the proximal femur (SSM Mode 2). There was a significant interaction between the rs288326 SNP and proximal femur shape (Mode 2) in predicting RHOA (p for interaction = 0.022). Among subjects with the rs288326 variant allele, there were increasing odds of RHOA with increasing quartiles of proximal femur shape Mode 2 (OR for 4th quartile of Mode 2 = 2.5, 95% confidence interval 1.2–5.3; p for linear trend = 0.02). The rs288326 and rs7775 FRZB SNPs are associated with the shape of the proximal femur. The presence of the rs288326 SNP alters the relationship between proximal femur shape and incident RHOA. Together, these findings suggest that FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.