Notch Signaling in Osteoblasts
Notch Signaling in Osteoblasts
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DOI：
10.1126/stke.117pe17
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发表时间：
2008-04-29
影响因子：
7.3
通讯作者：
Canalis, Ernesto
中科院分区：
文献类型：
--
作者：
Canalis, Ernesto
骨重建是形成新基质的成骨细胞和吸收骨的破骨细胞协调活动的结果。Notch蛋白是决定细胞命运的单程跨膜受体。最近的功能获得和功能丧失实验揭示了Notch在发育和出生后骨中的成骨细胞和破骨细胞分化中的抑制作用，这确立了Notch信号传导在骨重建中的作用。
Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.