In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics
In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics
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DOI：
10.1016/j.diagmicrobio.2022.115714
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发表时间：
2022-05-18
影响因子：
2.9
通讯作者：
Mitarai, Satoshi
中科院分区：
文献类型：
--
作者：
Aono, Akio;Murase, Yoshiro;Mitarai, Satoshi
目的：研究替地唑烷(TZD)对耐多药结核分枝杆菌的作用。这可能是第一个评估TZD对日本结核分枝杆菌分离株的MIC的研究。由于TZD的MIC明显低于LZD(P<；0.01)，因此被认为是一种更好的、无毒的LZD替代品。(C)2022 Elsevier Inc.保留所有权利。
The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD. (c) 2022 Elsevier Inc. All rights reserved.