Longitudinal changes in cerebral blood flow in the older hypertensive brain
Longitudinal changes in cerebral blood flow in the older hypertensive brain
复制标题
DOI：
10.1161/strokeaha.106.477109
复制
发表时间：
2007-06-01
期刊：
影响因子：
8.3
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Beason-Held, Lori L.;Moghekar, Abhay;Resnick, Susan M.
背景和目的：在巴尔的摩老龄化纵向研究中，评估了14名接受治疗的高血压患者(HTNS)和14名年龄匹配的健康老年参与者(健康对照[HCS])在6年时间里局部脑血流(RCBF)的变化。方法使用1、3、5和7年收集的静息状态PET扫描来确定HTNS和HCS之间rCBF变化的纵向模式的差异。HTN组脉压、动脉压、收缩/舒张压和高血压病程也与rCBF变化模式相关。结果：HTN组前额叶、前扣带回和枕区rCBF随时间的推移下降幅度较大，提示随着年龄的增长，这些区域更容易发生高血压相关功能障碍。HTN组也没有表现出随着时间的推移在运动区以及在颞叶皮质和海马区的功能保存，正如在HC观察到的那样。尽管脉压、平均动脉压、收缩压和舒张压都与纵向rCBF变化相似，但在HTN组中观察到的高血压病程延长与额叶前部和前扣带回功能易损区rCBF降低相关。结论--这些结果表明高血压显著影响老年人的静息脑功能，提示高血压病程对随时间变化的模式有显著贡献。
Background and Purpose - Changes in patterns of regional cerebral blood flow ( rCBF) were assessed over a period of 6 years in 14 treated hypertensive participants ( HTNs) and 14 age-matched healthy older participants ( healthy controls [ HCs]) in the Baltimore Longitudinal Study of Aging.Methods - Resting-state PET scans collected at years 1, 3, 5, and 7 were used to determine differences in longitudinal patterns of rCBF change in HTNs relative to HCs. Pulse pressure, arterial pressure, systolic/diastolic blood pressure, and hypertension duration were also correlated with patterns of rCBF change in the HTN group.Results - Relative to HCs, the HTN group shows greater rCBF decreases in prefrontal, anterior cingulate, and occipital areas over time, suggesting that these regions are more susceptible to hypertension-related dysfunction with advancing age. The HTN group also fails to show preservation of function over time in motor regions and in the temporal cortex and hippocampus as observed in HC. Although pulse pressure, mean arterial pressure, and systolic and diastolic pressure all correlate similarly with longitudinal rCBF changes, increased duration of hypertension is associated with decreased rCBF in prefrontal and anterior cingulate areas of functional vulnerability observed in the HTN group.Conclusions - These results show that hypertension significantly affects resting brain function in older individuals and suggest that duration of hypertension contributes significantly to the patterns of change over time.