Organelle transport during mouse oocyte differentiation in germline cysts
Organelle transport during mouse oocyte differentiation in germline cysts
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DOI：
10.1016/j.ceb.2016.12.002
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发表时间：
2017-02-01
影响因子：
7.5
通讯作者：
Lei, Lei
中科院分区：
文献类型：
--
作者：
Ikami, Kanako;Nuzhat, Nafisa;Lei, Lei
在哺乳动物卵子发生过程中，生殖细胞经历卵母细胞分化和卵母细胞发育以形成含有支持早期胚胎发生的必需成分的成熟卵母细胞。然而，只有一小部分生殖细胞成为成熟的卵母细胞，这种大量生殖细胞损失的机制尚不清楚。我们最近的研究表明，功能卵母细胞的形成和生殖细胞的损失是相互联系的“护理”过程中生殖细胞囊肿卵母细胞分化在小鼠胎儿卵巢。80%的胚胎生殖细胞通过将其细胞质内容物捐赠给剩余的姐妹生殖细胞而牺牲自己，这些姐妹生殖细胞分化成具有增强发育潜力的初级卵母细胞。本文就小鼠卵母细胞的分化过程进行综述，重点介绍生殖细胞包囊中细胞器的转运。
During mammalian oogenesis, germ cells undergo oocyte differentiation and oocyte development to form mature oocytes that contain essential components for supporting early embryogenesis. However, only a small fraction of germ cells become mature oocytes and the mechanism of this massive germ cell loss has been unclear. Our recent studies suggested that the formation of functional oocytes and germ cell loss are interlinked by a 'nursing' process in germline cysts during oocyte differentiation in mouse fetal ovaries. 80% of the fetal germ cells sacrifice themselves by donating their cytoplasmic contents to the remaining sister germ cells that differentiate into primary oocytes with augmented developmental potential. In this review, we will summarize the process of mouse oocyte differentiation with a particular focus on organelle transport in germline cysts.