Telomere shortening in women resident close to waste landfill sites
Telomere shortening in women resident close to waste landfill sites
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DOI：
10.1016/j.gene.2012.03.040
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发表时间：
2012-05-25
期刊：
影响因子：
3.5
通讯作者：
Guida, Maurizio
中科院分区：
文献类型：
--
作者：
De Felice, Bruna;Nappi, Carmine;Guida, Maurizio
几项研究表明，环境压力与健康指数下降之间存在联系，包括心血管疾病的风险因素、免疫功能下降和癌症风险。我们研究了一种假设，即污染作为一种环境压力，通过调节健康孕妇的细胞衰老速度来影响健康。我们的研究着眼于非法垃圾填埋场对意大利坎帕尼亚当地孕妇人口的影响。就像在非法倾倒中经常发生的情况一样，在人们还不知道土壤和水中的具体因素是什么之前，人们就已经看到了对人口的影响。在这里，我们提供的证据表明，该地区的污染与较高的氧化应激、较短的端粒长度和较低的端粒酶活性显著相关，这是已知的女性细胞衰老和衰老相关减数分裂功能障碍的决定因素，来自健康孕妇的外周血单核细胞，在妊娠中期接受治疗性流产。这些发现可能有助于理解在细胞水平上，环境压力如何促进年龄相关疾病的早期发病。(c) 2012 Elsevier B.V.版权所有
Several studies demonstrate links between environmental stress and index of reduced health, including risk factors for cardiovascular disease, reduced immune function and cancer risks. We investigated the hypothesis that pollution, as an environmental stress, impacts health by modulating the rate of cellular aging in healthy pregnant women.Our research looked at the effects that illegal waste sites have on the localized population of pregnant women in Campania, Italy. As is often the case in illegal dumping, the effects on the population are often seen well before knowing what specific agents in the soil and water are responsible. Here we provide evidence that the pollution in this region is significantly associated with higher oxidative stress, shorter telomere length and lower telomerase activity, which are known determinants of cell senescence and aging-related meiotic dysfunction in women, in peripheral blood mononuclear cells from healthy pregnant women, subjected to therapeutic abortion in the second trimester of pregnancy. These findings may have implications for understanding how, at the cellular level, environmental stress may promote earlier onset of age-related diseases. (c) 2012 Elsevier B.V. All rights reserved.