Connective tissue activation. II. Abnormalities of cultured rheumatoid synovial cells.
Connective tissue activation. II. Abnormalities of cultured rheumatoid synovial cells.
复制标题
结缔组织激活。
作者：
C. Castor;Susan F. Smith;James C. Ritchie;E. Dorstewitz
体外生长的类风湿滑膜细胞表现出：a）乳酸形成速率增加，b）葡萄糖摄取速率增加，c）透明质酸合成速率增加，d）对外源激活剂的敏感性降低，e）内源激活剂浓度增加。外源激活剂被证明能够诱导与抑制透明质酸合成相关的皮质醇无反应。外源性激活剂不会被滑膜细胞长期保留的证据表明，类风湿细胞中水平升高是由于内源性形成的加剧。类风湿滑膜细胞激活肽含量升高为体外正常滑膜细胞和类风湿滑膜细胞之间的许多差异提供了解释。
Rheumatoid synovial cells grown in vitro demonstrated: a) increased rate of lactate formation, b) increased rate of glucose uptake, c) increased rate of hyaluronate synthesis, d) decreased sensitivity to exogenous activator and e) increased concentrations of an endogenous activator. Exogenous activator was shown to be capable of inducing cortisol unresponsiveness in relation to suppression of hyaluronate synthesis. Evidence that exogenous activator is not long retained by synovial cells suggests that elevated levels in rheumatoid cells are due to accentuated endogenous formation. Elevated activator peptide content of rheumatoid synovial cells provides an explanation for many of the differences between normal and rheumatoid synovial cells in vitro.