Overcoming inhibition in the spindle checkpoint
Overcoming inhibition in the spindle checkpoint
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DOI：
10.1101/gad.1882109
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发表时间：
2009-12-15
影响因子：
10.5
通讯作者：
Hardwick, Kevin G.
中科院分区：
文献类型：
--
作者：
Vanoosthuyse, Vincent;Hardwick, Kevin G.
纺锤体检查点沉默是有丝分裂过程中启动染色体分离的关键步骤，但令人惊讶的是对其机制知之甚少。最近，蛋白磷酸酶 I (PP1) 被证明是这一过程中的关键参与者，在本期《基因与发展》中，Akiyoshi 及其同事（第 2887-2899 页）将芽殖酵母 Fin1p 确定为 PP1 活性针对检查点目标的动粒局部调节因子。在这里，我们回顾了最近的机制见解，并提出了主轴检查点沉默的工作模型。
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.