Mice lacking paternal expression of imprinted Grb10 are risk-takers
Mice lacking paternal expression of imprinted Grb10 are risk-takers
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缺乏印记 Grb10 父系表达的小鼠是冒险者
DOI：
10.1101/2020.02.25.962399
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Dent C
中科院分区：
文献类型：
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作者：
Dent C
印记基因Grb10和Nespin以相反的方式影响延迟贴现任务的冲动行为。最近发展的理论表明，这种行为模式可能代表了印记基因对风险耐受性的预测影响。在这里，我们检查缺乏 Grb10 父系表达的小鼠是否在一系列表明冒险的措施中表现出异常行为。尽管 Grb10+/pmice 在探索新环境的意愿方面与野生型（WT）同窝小鼠没有差异，但它们在明确的冒险测试（即捕食者气味冒险任务）中的行为表明冒险意愿增强。后续测试表明，这种冒险行为不仅仅是因为恐惧普遍减少，或者食物奖励动机普遍增加，而是反映了成本和奖励之间权衡的变化。这些数据，加上之前对延迟强化任务中 Grb10+/pmice 冲动行为的研究，以及我们对缺乏 motherNesp 的小鼠的研究，表明母本和父本表达的印记基因对冒险行为的影响与预测相反。
The imprinted genesGrb10andNespinfluence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on tolerance to risk. Here we examine whether mice lacking paternal expression ofGrb10show abnormal behavior across a number of measures indicative of risk‐taking. AlthoughGrb10+/pmice show no difference from wild type (WT) littermates in their willingness to explore a novel environment, their behavior on an explicit test of risk‐taking, namely the Predator Odor Risk‐Taking task, is indicative of an increased willingness to take risks. Follow‐up tests suggest that this risk‐taking is not simply because of a general decrease in fear, or a general increase in motivation for a food reward, but reflects a change in the trade‐off between cost and reward. These data, coupled with previous work on the impulsive behavior ofGrb10+/pmice in the delayed reinforcement task, and taken together with our work on mice lacking maternalNesp, suggest that maternally and paternally expressed imprinted genes oppositely influence risk‐taking behavior as predicted.