Dysregulation of immune homeostasis in autoimmune diseases
Dysregulation of immune homeostasis in autoimmune diseases
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DOI：
10.1038/nm.2621
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发表时间：
2012-01-01
期刊：
影响因子：
82.9
通讯作者：
Vinuesa, Carola G.
中科院分区：
文献类型：
--
作者：
Kuchroo, Vijay K.;Ohashi, Pamela S.;Vinuesa, Carola G.
我们对自身免疫性疾病的发病机制的理解已经取得了很大的进步。研究已经确定了遗传关联、效应T细胞和调节性T细胞的新功能亚群以及肠道微生物群是调节免疫功能的关键环境因素。这篇评论讨论了我们对遗传和环境因素的理解的最新进展，以及先天和适应性免疫反应在驱动免疫介导的组织损伤中的作用。
Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury.