Defective Viral Genomes: Critical Danger Signals of Viral Infections
Defective Viral Genomes: Critical Danger Signals of Viral Infections
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DOI：
10.1128/jvi.00707-14
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发表时间：
2014-08-01
影响因子：
5.4
通讯作者：
Lopez, Carolina B.
中科院分区：
文献类型：
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作者：
Lopez, Carolina B.
病毒有效地阻断宿主的抗病毒反应，以便在宿主干预之前复制和传播。在隐形病毒复制过程中启动抗病毒免疫的机制尚不清楚，但最近的数据表明，在病毒复制高峰时产生的缺陷病毒基因组对体内这一过程至关重要。本文总结了支持性证据，并强调了我们对自然感染过程中产生的免疫刺激缺陷病毒基因组的机制和影响的理解中的差距。
Viruses efficiently block the host antiviral response in order to replicate and spread before host intervention. The mechanism initiating antiviral immunity during stealth viral replication is unknown, but recent data demonstrate that defective viral genomes generated at peak virus replication are critical for this process in vivo. This article summarizes the supporting evidence and highlights gaps in our understanding of the mechanisms and impact of immunostimulatory defective viral genomes generated during natural infections.