How preserved is episodic memory in behavioral variant frontotemporal dementia?
How preserved is episodic memory in behavioral variant frontotemporal dementia?
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DOI：
10.1212/wnl.0b013e3181cef85d
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发表时间：
2010-02-09
期刊：
影响因子：
9.9
通讯作者：
Hodges, J. R.
中科院分区：
文献类型：
--
作者：
Hornberger, M.;Piguet, O.;Hodges, J. R.
目的：研究表明，行为变异型额颞叶痴呆（bvFTD）患者的记忆表现存在差异。我们的研究调查了这种变异性是否是由于真bvFTD患者和表型患者的混合所致。我们还试图比较bvFTD患者和阿尔茨海默病（AD）患者的表现。方法：我们分析了临床诊断为bvFTD的患者（分为进展患者（n = 50）和稳定患者（n = 39））、AD患者（n = 64）和健康对照（n = 64）的神经心理学记忆表现。结果：进行性bvFTD患者在大多数记忆测试中的受损水平与早期AD患者相似。一个确诊FTLD病理学的进展性bvFTD患者亚组（n = 10）的结果证实了这些结果。相比之下，表型bvFTD患者的表现显著优于进展者和AD患者。Logistic回归显示，bvFTD患者可通过单词列表学习测试的即时回忆评分在很高程度上（85%）区分（雷伊听觉语言学习测试）。结论：我们的研究结果为“真实的“或类似于阿尔茨海默病的进行性行为变异额颞叶痴呆（bvFTD）的潜在记忆缺陷提供了证据，尽管各组在定向评分上存在差异，bvFTD完整的患者。仅基于受损的神经心理学记忆表现排除可能导致FTD诊断不足。神经病学（R）2010; 74：472-479
Objective: Studies have shown variable memory performance in patients with behavioral variant frontotemporal dementia (bvFTD). Our study investigated whether this variability is due to the admixture of patients with true bvFTD and phenocopy patients. We also sought to compare performance of patients with bvFTD and patients with Alzheimer disease (AD).Methods: We analyzed neuropsychological memory performance in patients with a clinical diagnosis of bvFTD divided into those who progressed (n = 50) and those who remained stable (n = 39), patients with AD (n = 64), and healthy controls (n = 64).Results: Patients with progressive bvFTD were impaired on most memory tests to a similar level to that of patients with early AD. Findings from a subset of patients with progressive bvFTD with confirmed FTLD pathology (n = 10) corroborated these findings. By contrast, patients with phenocopy bvFTD performed significantly better than progressors and patients with AD. Logistic regression revealed that patients with bvFTD can be distinguished to a high degree (85%) on the immediate recall score of a word list learning test (Rey Auditory Verbal Learning Test).Conclusions: Our results provide evidence for an underlying memory deficit in "real"or progressive behavioral variant frontotemporal dementia (bvFTD) similar to Alzheimer disease, though the groups differ in orientation scores, with patients with bvFTD being intact. Exclusion solely based on impaired neuropsychological memory performance can potentially lead to an underdiagnosis of FTD. Neurology (R) 2010; 74: 472-479