COCAINE REINFORCED PROGRESSIVE RATIO PERFORMANCE IN RHESUS-MONKEY
COCAINE REINFORCED PROGRESSIVE RATIO PERFORMANCE IN RHESUS-MONKEY
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DOI：
10.1016/0091-3057(78)90214-9
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发表时间：
1978-01-01
影响因子：
3.6
通讯作者：
WILSON, MC
中科院分区：
文献类型：
--
作者：
BEDFORD, JA;BAILEY, LP;WILSON, MC
评估了递进比（PR）法测量几次静脉注射可卡因的相对强化效果的有效性。利用比先前报道的小得多的比例增加，动物通常表现出突破点的增加，可卡因单位剂量增加至每次注射0.4 mg/kg。所研究的最高剂量（每次注射0.8 mg/kg）产生的断点低于0.4 mg/kg剂量，但高于其余较低剂量。采用相同的强化计划，但以汤液作为奖励。这一过程将区分强化力量与更传统的奖励。研究了一种更方便的程序，看看能否在较短的时间内取得结果。较短的程序产生了过多的受试者内部变异性，表明在先前使用的5-7天和先前使用的50个强化反应之间的一些中间水平的基线经验对于获得一致的断点-单位剂量函数是必要的。
The effectiveness of a progressive ratio (PR) procedure in measuring the relative reinforcing efficacy of several i.v. doses of cocaine was assessed. Utilizing much smaller increases in the ratio requirement than previously reported, the animals generally displayed increases in breaking point with increases in the cocaine unit dose up to 0.4 mg/kg per inj [injection]. The highest dose studied (0.8 mg/kg per inj) engendered breaking points lower than the 0.4 mg/kg dose but higher than the remaining lower doses. The same reinforcement schedule was used but with liquid Tang as the reward. This procedure would function to discriminate reinforcing strength with a more traditional reward. A more expedient procedure was examined to see if results could be obtained in a shorter period of time. The shorter procedure engendered excessive intrasubject variability, suggesting that some intermediate level of baseline experience between the 5-7 days previously used and the 50 reinforced responses previously used would be necessary to obtain consistent breaking point-unit dose functions.