Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
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DOI：
10.1039/c3md00238a
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发表时间：
2013-12-01
期刊：
影响因子：
--
通讯作者：
Sun D
中科院分区：
文献类型：
--
作者：
Lin H;Annamalai T;Bansod P;Tse-Dinh YC;Sun D
Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
