A Precarious Balance: Pluripotency Factors as Lineage Specifiers
A Precarious Balance: Pluripotency Factors as Lineage Specifiers
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DOI：
10.1016/j.stem.2011.03.013
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发表时间：
2011-04-08
期刊：
影响因子：
23.9
通讯作者：
Lim, Bing
中科院分区：
文献类型：
--
作者：
Loh, Kyle M.;Lim, Bing
了解多能细胞不受限制的多谱系分化潜力的基础将具有发育和转化的后果。我们提出，多能性转录因子的谱系指定，直接承诺特定的胎儿谱系。个体因子赋予分化成特定细胞类型的能力，并且多能细胞内多个谱系特异性因子的伴随表达使得能够分化成每种胎儿谱系。此外，我们推测，而不是一个本质上稳定的“基态”，多能性是一个内在的不稳定的条件下，竞争对手的谱系指定符不断竞争指定分化沿着相互排斥的谱系。
Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of developmental and translational consequence. We propose that pluripotency transcription factors are lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent cells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an intrinsically stable "ground state," pluripotency is an inherently precarious condition in which rival lineage specifiers continually compete to specify differentiation along mutually exclusive lineages.