Hepatitis C infection among drug users in northern Thailand
Hepatitis C infection among drug users in northern Thailand
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DOI：
10.4269/ajtmh.2006.74.1111
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Nelson, Kenrad E.
中科院分区：
文献类型：
--
作者：
Jittiwutikarn, Jaroon;Thongsawat, Satawat;Nelson, Kenrad E.
非法吸毒者通常感染丙型肝炎病毒(丙型肝炎病毒)和人类免疫缺陷病毒(艾滋病毒)。我们评估了泰国北部1,859名吸毒者中与丙型肝炎病毒感染相关的流行率、发病率和危险行为。注射吸毒者的丙型肝炎病毒感染率为27.3%，吸毒者为86.0%，未注射者为5.3%。在吸毒者或吸毒者中，吸毒者或吸毒者的性行为与丙型肝炎病毒感染无关，多因素分析中仅注射行为与丙型肝炎病毒感染独立相关。在男性中，注射毒品史和日益频繁的注射毒品、年龄较大和监禁史与丙型肝炎病毒感染有关。在514例基线丙型肝炎病毒和艾滋病病毒血清阴性的阿片类药物使用者中，随访时发生了41例丙型肝炎病毒感染和6例艾滋病病毒感染，丙型肝炎病毒发病率为5.43/100人年，静脉注射吸毒者为44.3/100人年，非注射者为1.9/100人年。丙型肝炎病毒和艾滋病毒在泰国吸毒者中很常见，主要与注射行为有关。
Illicit drug users are commonly infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV). We evaluated the prevalence, incidence, and risk behaviors associated with HCV infection in 1,859 drug users in northern Thailand. The HCV prevalence was 27.3%: 86.0% among drug injectors (IDUs) and 5.3% among those who did not inject. Sexual behavior was not significantly associated with HCV among IDUs or drug users who used but didn't inject illicit drugs; only injection behaviors were independently associated with HCV in multivariate analysis. Among men, a history and increasing frequency of injecting drugs, older age, and a history of incarceration were associated with HCV infection. Among 514 opiate users who were HCV and HIV seronegative at baseline, 41 incident HCV infections and 6 HIV infections occurred on follow-up; the HCV incidence was 5.43/100 person-years; it was 44.3/100 person-years in IDUs and 1.9/100 person-years in non-injectors. HCV and HIV among drug users in Thailand are common and primarily associated with injection behavior.