Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg
Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg
复制标题
DOI：
10.1016/j.ntt.2004.12.001
复制
发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Muckle, G
中科院分区：
文献类型：
--
作者：
Després, C;Beuter, A;Muckle, G
本研究旨在探讨出生前和出生后长期接触汞(Hg)、多氯联苯(PCbs)和铅(PbS)对学龄前儿童神经运动发育的影响。研究人群包括110名来自努纳维克(加拿大)的学龄前因纽特儿童。在出生时(脐带血)和检测时测量血液中汞、多氯联苯和铅的浓度。评估患者的粗大运动功能，并进行神经学检查。通过手部姿势震颤、反应时间、摆动摆动以及交替和定点运动的定量测量来评估精细神经运动能力。潜在的协变量包括人口学和家族特征、其他产前神经毒物(酒精、烟草)和营养素(硒、欧米茄-3多不饱和脂肪酸)。进行分层多元回归分析，控制有意义的协变量。粗大运动发育与产前暴露无关。然而，在测试时的血铅浓度与反应时间、摆动摆动、手臂交替运动和动作震颤的变化之间存在显著的相关性。对于其中一些结果，铅暴露的神经运动效应在血液浓度低于10微克/分升时被观察到。多氯联苯对神经运动发育的负面影响并不明显，n-3多不饱和脂肪酸和硒的潜在益处也没有观察到。震颤的幅度与检测时的血汞浓度有关，这证实了在成年人中已有报道的影响。(C)2004 Elsevier Inc.保留所有权利。
The aim of this study was to examine the effects of prenatal and postnatal chronic exposure to mercury (Hg), polychlorinated biphenyls (PCBs) and lead (Pb) on the neuromotor development of preschool children. The study population consisted of 110 preschool Inuit children from Nunavik (Canada). Blood Hg, PCBs and Pb concentrations were measured at birth (cord blood) and at the time of testing. Gross motor functions were evaluated and a neurological examination was performed. Fine neuromotor performance was assessed using quantitative measures of postural hand tremor, reaction time, sway oscillations, as well as alternating and pointing movements. Potential covariates were documented including demographic and familial characteristics, other prenatal neurotoxicants (alcohol, tobacco) and nutrients (selenium (Se), Omega-3 polyunsaturated fatty acids (n-3 PUFA)). Hierarchical multivariate regression analyses were performed, controlling for significant covariates. Gross motor development was not linked to prenatal exposures. However, significant associations were observed between blood Pb concentration at testing time and changes in reaction time, sway oscillations, alternating arm movements and action tremor. For some of these outcomes, neuromotor effects of Pb exposure are observed at blood concentrations below 10 mu g/dl. Negative effects of PCBs on neuromotor development were not clearly observed, neither were the potential beneficial effects of n-3 PUFA and selenium. Tremor amplitude was related to blood Hg concentrations at testing'time, which corroborate an effect already reported among adults. (c) 2004 Elsevier Inc. All rights reserved.