Social reversal of immunosenescence in honey bee workers
Social reversal of immunosenescence in honey bee workers
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DOI：
10.1016/j.exger.2005.08.004
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发表时间：
2005-12-01
影响因子：
3.9
通讯作者：
Hartfelder, K
中科院分区：
文献类型：
--
作者：
Amdam, GV;Aase, ALTO;Hartfelder, K
免疫衰老的一个显着例子是蜜蜂（Apis mellifera）工蜂种姓。蜜蜂随着年龄的增长，从蜂巢职责转向风险更大的觅食活动，这与免疫力的急剧下降有关。明确地表明，保幼激素（JH）水平的增加，伴随着觅食行为的开始，通过核固缩诱导广泛的血细胞死亡。在这里，我们证明，被迫恢复蜂巢任务的觅食者表现出免疫衰老的逆转，即随着年龄的增长免疫力的恢复。这种由社会操纵引发的恢复伴随着内源性 JH 滴度的下降和血淋巴卵黄蛋白原水平的增加。卵黄原蛋白是一种锌结合糖脂蛋白，与蜜蜂免疫完整性的调节有关。我们还确定工人免疫衰老是由细胞凋亡介导的，证实了免疫衰老的逆转是通过新细胞的增殖而出现的。因此，本文提供的结果揭示了蜜蜂免疫的独特灵活性——一种可能具有普遍生物学意义的调节可塑性。(c) 2005 Elsevier Inc. 保留所有权利。
A striking example of immunosenescence is seen in the honey bee (Apis mellifera) worker caste. The bees' age-associated transition from hive duties to more risky foraging activities is linked to a dramatic decline in immunity. Explicitly, it has been shown that an increase in the juvenile hormone (JH) level, which accompanies onset of foraging behavior, induces extensive hemocyte death through nuclear pycnosis. Here, we demonstrate that foragers that are forced to revert to hive-tasks show reversal of immunosenescence, i.e. a recovery of immunity with age. This recovery, which is triggered by a social manipulation, is accompanied by a drop in the endogenous JH titer and an increase in the hemolymph vitellogenin level. Vitellogenin is a zinc binding glycolipoprotein that has been implicated in the regulation of honey bee immune integrity. We also establish that worker immuno senescence is mediated by apoptosis, corroborating that reversal of immumosenescence emerges through proliferation of new cells. The results presented here, consequently, reveal a unique flexibility in honey bee immunity-a regulatory plasticity that may be of general biological interest.(c) 2005 Elsevier Inc. All rights reserved.