Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International.
Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International.
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DOI：
10.1016/j.ocarto.2020.100026
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发表时间：
2020-03
期刊：
影响因子：
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通讯作者：
Fischer, Arielle G
中科院分区：
文献类型：
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作者：
Andriacchi, Thomas P;Griffin, Timothy M;Loeser, Richard F Jr;Chu, Constance R;Roos, Ewa M;Hawker, Gillian A;Erhart-Hledik, Jennifer C;Fischer, Arielle G
激发未来的研究方向，在不同学科之间寻求骨关节炎（OA）的解决方案，并将骨关节炎（OA）作为一种严重的疾病，其复杂性已经为寻找安全有效的解决方案提供了障碍。在骨科研究学会（ORS）和国际骨关节炎研究学会（OARSI）的2019年会议上进行了会议，包括来自影像学，力学，生物标志物，表型，临床，流行病学，炎症和运动的领先OA研究人员提交的演讲和问题/评论。OA的解决方案需要在研究和临床方法上进行范式转变，将OA视为一种复杂的全身/个人疾病。需要新的OA定义/表型和OA标记/信号来解决疾病的遗传和环境因素之间的相互作用，以及捕获疾病的机械敏感性。提出“机械因子”一词是为了强调将全身力学作为早期OA标志的重要性。在将OA视为一个复杂系统的背景下，还讨论了新的干预措施和明显的矛盾观察/问题（例如锻炼与负荷调节）。为了推进安全有效的OA新疗法，OA应被视为一种“全人”疾病。这种方法需要协调一致的努力来跨越学科，包括从分子到整个身体，包括心理社会方面的尺度的相互作用。
To stimulate future research directions that seek solutions for osteoarthritis (OA) at the interface between diverse disciplines and address osteoarthritis (OA) as a serious disease with a complexity that has presented a barrier to finding safe effective solutions. Sessions were conducted at the 2019 meetings of the Orthopaedic Research Society (ORS) and Osteoarthritis Research Society International (OARSI) that included presentations and questions/comments submitted from leading OA researchers representing imaging, mechanics, biomarkers, phenotyping, clinical, epidemiology, inflammation and exercise. Solutions for OA require a paradigm shift in research and clinical methods in which OA is contextualized as a complex whole-body/person disease. New OA definition(s)/phenotype(s) and OA markers/signals are needed to address the interplay between genetic and environmental factors of the disease as well as capture the mechanosensitivity of the disease. The term “Mechanokines” was proposed to highlight the importance of incorporating whole body mechanics as a marker of early OA. New interventions and apparent paradoxical observations/questions (e.g. exercise vs. load modification) were also discussed in the context of considering OA as a complex system. To advance new OA treatments that are safe and effective, OA should be considered as a “Whole Person” disease. This approach requires a concerted effort to bridge disciplines and include interactions across scales from the molecule to the whole body, including psychosocial aspects.