The Relation Between Water Intake and Food Intake in Normal Rats and in Rats with Hypothalamic Hyperphagia *
The Relation Between Water Intake and Food Intake in Normal Rats and in Rats with Hypothalamic Hyperphagia *
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正常大鼠和下丘脑食欲亢进大鼠的水摄入量和食物摄入量之间的关系*
DOI：
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发表时间：
1947
期刊：
影响因子：
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通讯作者：
J. Strominger
中科院分区：
文献类型：
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作者：
J. Strominger
Babinski，2 Fr'ohlich，18和Erdheim 16描述的患有脑底部病变的患者的肥胖症现在已经在狗，20 24猫，32猴，9和大鼠中实验产生。此外，关于原发性病变是否在垂体中的长期存在的争议4' 12，18（如Fr'ohlich“8最初提出的）或下丘脑16 22，30（如Erdheim首次提出的）似乎已经解决，当Hetherington 21表明脑垂体不参与肥胖的发展，大鼠下丘脑腹内侧的双侧对称病变。Hetherington和Ranson23以前曾表明，在放置这些损伤后，在垂体中没有检测到明显的变化。到目前为止，还没有发现这些动物中间代谢的主要障碍，因为观察到的变化似乎是“过度进食的结果，而不是病变的结果。7”3目前的工作倾向于强调肥胖是能量交换基本障碍的结果的假设。5过度进食的机制目前尚不清楚，虽然可能是某些代谢紊乱引起的，但这种紊乱的性质完全是神经性的。临床研究者也强调了摄食过多在人类肥胖症发病机制中的重要性。“113，25，29由于视上核（其病变产生尿崩症“7）位于病变区域的正前方，
The obesity described by Babinski,2 Fr'ohlich,18 and Erdheim16 in patients suffering from lesions at the base of the brain has now been produced experimentally in the dog,20 24 cat,32 monkey,9 and rat.6 8 Moreover, the long-existing controversy as to whether the primary lesion is in the hypophysis4' 12, 18 (as originally suggested by Fr'ohlich"8) or in the hypothalamus16 22, 30 (as Erdheim"6 first proposed) seems to have been settled when Hetherington21 showed that the pituitary is not involved in the development of the obesity which follows the production of discrete, bilaterally symmetrical lesions in the ventromedial hypothalamus of the rat. Hetherington and Ranson23 had previously shown that following the placing of these lesions no conspicuous changes could be detected in the pituitary. Thus far no primary disturbance in the intermediary metabolism of these animals has been discovered, since the alterations observed seem to'be the consequence of the hyperphagia rather than the result of the lesion.7' 3 Present work tends to emphasize the hypothesis that the obesity is a result of a fundamental disturbance of energy exchange.5 The mechanism of the hyperphagia is at present unknown, and, while it is possible that some metabolic disturbance may be responsible for it, -the n.ature of such a disturbance is wholly conjectural. Clinical investigators also have emphasized the importance of hyperphagia in the pathogenesis of human obesity."1 13, 25, 29 Since the supra-optic nucleus (lesions of which produce diabetes insipidus"7) lies just anterior to the region where the lesions are