SUBCORTICAL MECHANISMS IN EMOTIONAL BEHAVIOR - THE DURATION OF AFFECTIVE CHANGES FOLLOWING SEPTAL AND HABENULAR LESIONS IN THE ALBINO RAT
SUBCORTICAL MECHANISMS IN EMOTIONAL BEHAVIOR - THE DURATION OF AFFECTIVE CHANGES FOLLOWING SEPTAL AND HABENULAR LESIONS IN THE ALBINO RAT
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DOI：
10.1037/h0046406
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发表时间：
1955-01-01
期刊：
影响因子：
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通讯作者：
NAUTA, WJH
中科院分区：
文献类型：
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作者：
BRADY, JV;NAUTA, WJH
本实验进一步研究了白化病大鼠前脑隔区和丘脑缰复合体损伤后行为变化的持续时间和特征。在术前和术后，收集关于（a）“恐惧”或“焦虑”类型的条件性情绪反应（CER）的获得、保持和消退，（B）惊吓反应的程度，以及（c）七项评定量表中反映的一般情绪反应的数据。结果证实了先前报告的中隔动物的情绪反应和惊吓反应的程度在术后增加，但不是缰动物。所有动物在术后60天内恢复正常。12只间隔动物中有6只显示术后CER强度暂时降低，这显然与穹窿系统和丘脑前核的受累程度有关。缰病变对CER的获得或保留没有影响，但缰动物的情感反应消失明显更快。这种效应似乎与缰核复合体的损伤程度有关。
Experiments investigate further the duration and specific character of behavioral changes in albino rats following lesions in the septal forebrain region and habenular complex of the thalamus. Both pre- and post-operatively, data were collected with respect to (a) the acquisition, retention, and extinction of a conditioned emotional reponse (CER) of the "fear" or "anxiety" type, (b) the magnitude of the startle response, and (c) general emotional reactivity as reflected in a seven-item rating scale. The results confirmed the previously reported post-operative increase in magnitude of both emotional reactivity and startle response for the septal animals, but not the habenula animals. All animals returned to normal within 60 days after operation. Six of the twelve septal animals showed a temporary reduction in the strength of the CER post-operatively, apparently related to the extent of involvement of the fornix system and anterior thalamic nuclei. Habenular lesions produced no effect upon the acquisition or retention of the CER, but extinction of the emotional response was significantly more rapid in the habenula animals. This effect seemed to be related to the extent of the damage to the habenular complex.