Antistreptococcal, neuronal, and nuclear antibodies in Tourette syndrome
Antistreptococcal, neuronal, and nuclear antibodies in Tourette syndrome
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DOI：
10.1016/s0887-8994(02)00507-6
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发表时间：
2003-02-01
影响因子：
3.8
通讯作者：
Singer, HS
中科院分区：
文献类型：
--
作者：
Loiselle, CR;Wendlandt, JT;Singer, HS
先前的研究表明，抽动秽语综合征和注意缺陷多动障碍与抗链球菌抗体之间以及抽动秽语综合征与抗核抗体之间存在关联。在这项研究中，抗链球菌溶血素O，抗脱氧核糖核酸酶B，抗核抗体，抗神经元抗体测定41例儿童抽动秽语综合征和38名对照组，选择不考虑链球菌感染史。结果显示，平均抗链球菌滴度没有诊断组之间的差异。此外，多元回归分析无法根据年龄和诊断预测抗链球菌抗体滴度。抗链球菌溶血素0滴度升高的频率，基于1：240的截止值，注意缺陷多动障碍患者（64%）显著高于无注意缺陷多动障碍组（34%）（P = 0.04），但根据年龄匹配的正常值进行二分时则无差异。抗脱氧核糖核酸酶B滴度分析未发现组间存在任何差异。抗核抗体滴度至少为1：160在3的33抽动秽语综合征患者，只有一个主题表现出均匀的染色模式。根据年龄、诊断和抗链球菌滴度的组合，多元回归分析无法预测抗核、抗神经元或抗HTB-10抗体滴度。我们建议，纵向，而不是单点的时间实验室测量进行评估，然后得出明确的结论之间的关联，抽动秽语综合征，注意缺陷多动障碍，强迫症和抗链球菌或抗核抗体滴度的诊断。(C)2003年，Elsevier Inc. All rights reserved.
Previous studies have suggested associations between Tourette syndrome and attention-deficit-hyperactivity disorder and antistreptococcal antibodies and between Tourette syndrome and antinuclear antibodies. In this study, antistreptolysin O, antideoxyribonuclease B, antinuclear, and antineuronal antibodies were measured in 41 children with Tourette syndrome and 38 controls, selected without regard to history of streptococcal infection. Results revealed that mean antistreptococcal titers did not differ between diagnostic groups. In addition, multiple regression analysis was unable to predict antistreptococcal antibody titers according to age and diagnosis. The frequency of elevated antistreptolysin 0 titers, based on a cutoff of 1:240, was significantly higher (P = 0.04) in patients with attention-deficit-hyperactivity disorder (64%) than in the group without attention-deficit-hyperactivity disorder (34%) but not when dichotomized according to age-matched normal values. No analysis of antideoxyribonuclease B titers identified any differences between groups. Antinuclear antibody titers were at least 1:160 in three of 33 Tourette syndrome patients; only one subject manifested a homogeneous staining pattern. Multiple regression analyses were unable to predict antinuclear, antineuronal, or anti-HTB-10 antibody titers according to the combination of age, diagnosis, and antistreptococcal titer. We suggest that longitudinal rather than single-point-in-time laboratory measurements be evaluated before definitive conclusions are drawn on associations between the diagnosis of Tourette syndrome, attention-deficit-hyperactivity disorder, or obsessive-compulsive disorders and antistreptococcal or antinuclear antibody titers. (C) 2003 by Elsevier Inc. All rights reserved.