The emerging roles of circular RNAs in regulating the fate of stem cells
The emerging roles of circular RNAs in regulating the fate of stem cells
复制标题
环状RNA在调节干细胞命运中的新作用
DOI：
10.1007/s11010-020-03900-w
复制
发表时间：
2020
影响因子：
4.3
通讯作者：
Yunfei Zheng
中科院分区：
文献类型：
--
作者：
Ziyao Zhuang;Lingfei Jia;Weiran Li;Yunfei Zheng
环状RNA（circular RNA，circRNA）是一类具有共价闭合环状结构的RNA，近年来已成为研究热点。干细胞是一种未分化的细胞，由于其自我更新能力和分化能力，在医学治疗方面具有巨大的潜力。大量研究表明，circRNA在干细胞分化过程中具有独特的表达模式，有望成为干细胞分化的生物标志物。存在与干细胞的分化、增殖和凋亡相关的关键circRNA，其具有某些机制，例如海绵状miRNA、与蛋白质相互作用和干扰mRNA翻译。此外，几种circRNA已经加入干细胞和淋巴细胞之间的相互作用。我们的综述将揭示circRNA在调节不同干细胞命运中的新作用。
Circular RNAs(circRNAs) are a large family of RNAs shaping covalently closed ring-like molecules and have become a hotspot with thousands of newly published studies. Stem cells are undifferentiated cells and have great potential in medical treatment due to their self-renewal ability and differentiation capacity. Abundant researches have unveiled that circRNAs have unique expression profile during the differentiation of stem cells and could serve as promising biomarkers of these cells. There are key circRNAs relevant to the differentiation, proliferation, and apoptosis of stem cells with certain mechanisms such as sponging miRNAs, interacting with proteins, and interfering mRNA translation. Moreover, several circRNAs have joined in the interplay between stem cells and lymphocytes. Our review will shed lights on the emerging roles of circRNAs in regulating the fate of diverse stem cells.