Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.
Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.
复制标题
个体 KIAA0319 多态性与人群中发育性阅读障碍风险之间的相反关联：研究人群的分层荟萃分析
DOI：
10.1038/srep30454
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发表时间：
2016-07-28
影响因子：
4.6
通讯作者：
Song R
中科院分区：
文献类型：
--
作者：
Shao S;Niu Y;Zhang X;Kong R;Wang J;Liu L;Luo X;Zhang J;Song R
DYX 2基因座上的KIAA 0319是发育性阅读障碍（DD）的候选基因之一，由于其在神经元迁移中的重要作用而被广泛研究。先前关于KIAA 0319遗传变异与DD之间关联的研究得出了不一致的结果。重要的是要建立一个更精确的估计与这些遗传变异相关的DD风险。我们对涉及KIAA 0319多态性和DD风险的关联研究进行了荟萃分析。合并分析的结果表明，在KIAA 0319基因内或附近的6个标记中没有一个与DD相关。然而，研究人群的分层分析显示，在欧洲和亚洲亚组中，KIAA 0319 rs 4504469的相关性相反。分层分析还显示，KIAA 0319 rs 9461045次要等位基因（T等位基因）在亚洲人中具有保护作用。这项荟萃分析使我们能够更精确地确定特定KIAA 0319多态性对DD风险的影响，因为它们在不同人群中存在差异;一次分析一个单核苷酸多态性不能完全解释DD的遗传关联。
KIAA0319 at the DYX2 locus is one of the most extensively studied candidate genes for developmental dyslexia (DD) owing to its important role in neuronal migration. Previous research on associations between KIAA0319 genetic variations and DD has yielded inconsistent results. It is important to establish a more precise estimate of the DD risk associated with these genetic variations. We carried out a meta-analysis of association studies involving KIAA0319 polymorphisms and DD risk. The results of pooled analysis indicated that none of the six investigated markers in or near the KIAA0319 gene are associated with DD. However, a stratified analysis by the study population revealed opposite associations involving KIAA0319 rs4504469 in European and Asian subgroups. The stratified analysis also showed that the KIAA0319 rs9461045 minor allele (T allele) has a protective effect in Asians. This meta-analysis has allowed us to establish the effects of specific KIAA0319 polymorphisms on DD risk with greater precision, as they vary across populations; analyzing one single nucleotide polymorphism at a time could not fully explain the genetic association for DD.