Dynamics of lung collapse and recruitment during prolonged breathing in porcine lung injury
Dynamics of lung collapse and recruitment during prolonged breathing in porcine lung injury
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DOI：
10.1152/jappl.1998.85.4.1533
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发表时间：
1998-10-01
影响因子：
3.3
通讯作者：
Hedenstierna, G
中科院分区：
文献类型：
--
作者：
Neumann, P;Berglund, JE;Hedenstierna, G
油酸（OA）注射、肺灌洗和内毒素输注是三种常用的诱导实验性肺损伤的方法。这些模型中肺塌陷和肺复张的动态尚未得到研究，尽管了解这一点对于建立保持肺部开放的通气技术是必要的。我们在屏气过程中通过计算机断层扫描测量了肺密度。用 OA、肺灌洗或内毒素对 6 只机械通气猪进行分组，诱导肺损伤。稳定期后，在有或没有呼气末正压的长时间呼气期间以及在呼气 5 秒和 30 秒后长时间吸气期间，获得同一切片的重复计算机断层扫描。在所有三种肺损伤模型中，肺塌陷和复张主要发生在屏气操作的前4秒内，甚至在0.6秒内也发生了一些塌陷和复张。 OA损伤的肺明显比支气管肺泡灌洗或内毒素输注损伤的肺更不稳定。在此实验设置中，过期时间
Oleic acid (OA) injection, lung lavage, and endotoxin infusion are three commonly used methods to induce experimental lung injury. The dynamics of lung collapse and recruitment in these models have not been studied, although knowledge of this is desirable to establish ventilatory techniques that keep the lungs open. We measured lung density by computed tomography during breath-holding procedures. Lung injury was induced with OA, lung lavage, or endotoxin in groups of six mechanically ventilated pigs. After a stabilization period, repetitive computed tomography scans of the same slice were obtained during prolonged expirations with and without positive end-expiratory pressure and during prolonged inspirations after 5 and 30 s of expiration. Lung collapse and recruitment occurred mainly within the first 4 s of breath-holding procedures in all three lung injury models, and some collapse and recruitment occurred even within 0.6 s. OA-injured lungs were significantly more unstable than lungs injured by bronchoalveolar lavage or endotoxin infusion. In this experimental setting, expiration times