Thymoglobulin induction dosing strategies in a low-risk kidney transplant population: three or four days?
Thymoglobulin induction dosing strategies in a low-risk kidney transplant population: three or four days?
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低风险肾移植人群的胸腺球蛋白诱导给药策略：三天还是四天？
DOI：
10.1155/2010/957549
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发表时间：
2010
影响因子：
2.5
通讯作者：
Brennan,DanielC
中科院分区：
文献类型：
--
作者：
Hardinger,KarenL;Rasu,RafiaS;Skelton,Rebecca;Miller,BrentW;Brennan,DanielC
兔抗胸腺细胞球蛋白（rATG）诱导的最佳剂量和持续时间尚未确定。我们在一项回顾性队列研究中比较了两种给药策略的安全性和有效性，rATG 1.5 mg/kg持续4天（n= 59）与2 mg/kg持续3天（n= 59）。 两组的2年无排斥生存率均为95%（P= 0.983）。肾功能和感染率相似。白细胞减少症的发生率相似，尽管2 mg/kg组在第2天更可能出现白细胞减少症（4% vs 28%，P = 0.04）。1.5 mg/kg组的住院时间往往更长（6.0 ± 3.7 vs 5.1 ± 1.9天P = 0.104）。2 mg/kg组每例患者rATG的成本节省为920美元（P= 0.122）。更短、更强剂量的rATG是安全有效的。3天给药策略缩短了临床住院时间，并可能节省成本。
The optimal dose and duration of rabbit antithymocyte globulin (rATG) induction has not been defined.Methods. We compared the safety and efficacy of 2 dosing strategies, rATG 1.5 mg/kg for 4 days (n= 59) versus 2 mg/kg for 3 days (n= 59), in a retrospective, cohort study.Results. Two‐year rejection‐free survival was 95% in each group (P= .983). Renal function and infection rates were similar. The incidence of leucopenia was similar, although the 2 mg/kg group was more likely to be thrombocytopenic on day 2 (4% versus 28%,P= .04). Length of stay tended to be longer for the 1.5 mg/kg group (6.0 ± 3.7 versus 5.1 ± 1.9 daysP= .104). A cost savings of $920 per patient for rATG were seen in the 2 mg/kg group (P= .122).Conclusions. Shorter, more intense dosing of rATG is safe and effective. The 3‐day dose strategy resulted in a clinically shorter length of stay and may result in cost savings.