Mitochondria1 respiratory chain activity in skeletal muscle from patients with Parkinson's disease
Mitochondria1 respiratory chain activity in skeletal muscle from patients with Parkinson's disease
复制标题
帕金森病患者骨骼肌线粒体1呼吸链活性
作者：
Francesc Cardellach;M. J. Martí;J. Fernandez;C. Marín;Jan B. Hoek;Eduard Tolosa;Alvaro Urbano
在特发性帕金森病（PD）患者的肌肉和其他组织中，线粒体电子传递链活性的不同异常已被证实。我们研究了8名西班牙PD患者，以评估该国家患者肌肉线粒体中电子传递链的功能活性。我们发现患者的复合体I活性（nmol.min-1.mg−1）（245.8±42.8）低于对照组（331.6±60.1）（p = 0.004），复合体IV活性（46.1±9）低于对照组（144.1±42.3）（p = 0.00001）。2例患者复合体V活性降低，复合体II和III活性正常。尽管这些结果强烈提示帕金森病患者线粒体DNA的改变，但不同组织中的各种电子传递链缺陷似乎是非特异性的。
Different abnormalities in mitochondrial electron transport chain activity have been demonstrated in muscle and other tissues of patients with idiopathic Parkinson's disease (PD). We studied eight Spanish patients with PD to evaluate the functional activity of the electron transport chain in muscle mitochondria from patients of this country. We found lower complex I activity (nmol.min-1.mg−1) in patients (245.8 ± 42.8) than in controls (331.6 ± 60.1) (p = 0.004) and lower complex IV activity in patients (46.1 ± 9) than in controls (144.1 ± 42.3) (p = 0.00001). Complex V activity was also decreased in two patients and complex II and III activities were normal in all of them. Although these results strongly suggest an alteration in mitochondrial DNA in PD, the various electron transport chain defects in different tissues seem to be nonspecific.