The pathophysiology of neurofibromatosis: IX. Paternal age as a factor in the origin of new mutations.
The pathophysiology of neurofibromatosis: IX. Paternal age as a factor in the origin of new mutations.
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神经纤维瘤病的病理生理学：IX。
DOI：
10.1002/ajmg.1320180121
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bontke,C
中科院分区：
文献类型：
--
作者：
Riccardi,VM;Dobson2nd,CE;Chakraborty,R;Bontke,C
冯·雷克林豪森神经纤维瘤病的特点是明显非家族性病例的比例相对较大，推测为自发突变。本文分析了187例确诊的von Reckinghausen病患者的父亲和母亲的年龄分布。父亲的平均年龄为32.8岁，母亲的平均年龄为27.4岁，均显著大于对照组(P<0.05)。001)。母亲年龄的增加并不能解释父亲的高龄。描述了控制每个患者出生年份的总体人口父代年龄的方法。
Von Recklinghausen neurofibromatosis is characterized by a relatively large proportion of apparently nonfamilial cases, presumed spontaneous mutations. This paper analyzes the distribution of paternal and maternal ages for 187 patients with von Recklinghausen disease representing the first definite case in their respective families. Mean paternal age was 32.8 years and mean maternal age was 27.4 years, both being significantly greater than for control populations (P equal to or less than. 001). The advanced paternal age was not accounted for by the increase in maternal age. The methodology of controlling the general population paternal ages for each patient's birth year is described.