Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model
Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model
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DOI：
10.1097/00003643-200305000-00011
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发表时间：
2003-05-01
影响因子：
3.6
通讯作者：
Ueda, S
中科院分区：
文献类型：
--
作者：
Okuda, K;Takanishi, T;Ueda, S
背景与目的：盐酸曲唑酮用于治疗神经病理性疼痛。然而，曲唑酮对神经病理性疼痛的镇痛作用存在争议。方法：采用大鼠坐骨神经慢性压迫性损伤模型，观察曲唑酮对大鼠坐骨神经慢性压迫性损伤引起的热痛敏的影响，并观察5，7-二羟基曲丁胺（5，7-DHT）对大鼠坐骨神经下行和上行神经元能系统损伤的影响。曲唑酮的镇痛作用呈明显的剂量依赖性。此外，在大鼠中缝背核和中缝内侧核注射5，7-二氢睾酮，观察曲唑酮的镇痛作用。结论：结果表明，一个主要由多巴胺能下行痛控制通路介导的曲唑酮的镇痛作用。
Background and objective: Trazodone hydrochloride is used in the treatment of neuropathic pain. However, the analgesic effects of trazodone on neuropathic pain are controversial. The study was undertaken to determine the analgesic effect of trazodone on a chronic constriction injury model.Methods: We tested the effect of trazodone on thermal hyperalgesia due to a chronic constriction injury of the sciatic nerve in rats and examined the effects of lesions in the descending and ascending serotonergic system induced by 5,7-dihydroxytriptamine (5,7-DHT).Results: The analgesic effects of trazodone showed a clear dose dependency. Furthermore, the analgesic effect of trazodone was observed in rats injected with 5,7-DHT into the dorsal raphe nucleus and medial raphe nucleus.Conclusions: The results suggest that a mainly serotonergic descending pain control pathway mediates the analgesic effects of trazodone.