Identification of the true human orthologue of the mouse Zp1 gene:: evidence for greater complexity in the mammalian zona pellucida?
Identification of the true human orthologue of the mouse Zp1 gene:: evidence for greater complexity in the mammalian zona pellucida?
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DOI：
10.1016/s0167-4781(99)00181-5
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发表时间：
1999-10-28
期刊：
影响因子：
--
通讯作者：
Barratt, CLR
中科院分区：
文献类型：
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作者：
Hughes, DC;Barratt, CLR
哺乳动物透明质酸是一种糖蛋白的混合物，被认为是由三个不同的基因编码，ZP 1/ZPB，ZP 2/ZPA和ZP 3/ZPC。我们现在已经确定，真正的人类直系同源的小鼠ZP 1基因不是ZPB，但有一个独特的人类ZP 1基因。人ZP 1和鼠ZP 1基因的比较表明核苷酸和氨基酸序列、内含子-外显子大小和组织以及调控序列的显著保守性。此外，小鼠和人类ZP 1基因位于人类11号染色体和小鼠19号染色体之间的保守同线性区域。(C)1999 Elsevier Science B. V.保留所有权利。
The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19. (C) 1999 Elsevier Science B.V. All rights reserved.