The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens.
The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens.
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粘液样脂肪肉瘤组织学谱的扩展，重点是新描述的模式：对小活检标本诊断的影响。
DOI：
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发表时间：
2012
影响因子：
3.5
通讯作者：
B. Rubin
中科院分区：
文献类型：
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作者：
K. Fritchie;J. Goldblum;R. Tubbs;Yang Sun;Paula Carver;S. Billings;B. Rubin
黏液样脂肪肉瘤的组织学类型的多样性被低估了。这些模式的多样性可能导致诊断困难。我们通过对46例原发、复发和转移性黏液样脂肪肉瘤的活检和切除标本进行分类和描述，研究了黏液样脂肪肉瘤的形态谱。46例中发现的类型包括传统黏液样（43例[93%]）、传统圆细胞（17例[37%]）、假腺泡（24例[52%]）、富脂肪细胞（13例[28%]）、岛状（11例[24%]）、脂肪瘤样（10例[22%]）、间质透明化（7例[15%]）、索样（5例[11%]）、巢状（3例[7%]）、软骨样化生（2例[4%]）和血管外皮细胞瘤样（1例[2%]）。岛屿和嵌套模式以前没有被描述过。通过DDIT3（也称为CHOP）重排的荧光原位杂交研究证实了黏液样脂肪肉瘤的诊断。黏液样脂肪肉瘤的形态范围远远超出其典型的黏液样基质中梭形细胞的外观，具有明显的血管模式。意识到各种组织学模式是至关重要的，以避免误诊，特别是在小活检标本。
The variety of histologic patterns in myxoid liposarcoma is underappreciated. The diversity of these patterns can lead to diagnostic difficulty. We examined the morphologic spectrum of myxoid liposarcoma by cataloguing and describing different patterns identified in biopsy and resection specimens of 46 primary, recurrent, and metastatic myxoid liposarcomas. The patterns identified in the 46 cases included traditional myxoid (43 [93%]), traditional round cell (17 [37%]), pseudoacinar (24 [52%]), lipoblast-rich (13 [28%]), island (11 [24%]), lipomatous (10 [22%]), stromal hyalinization (7 [15%]), cord-like (5 [11%]), nested (3 [7%]), chondroid metaplasia (2 [4%]), and hemangiopericytoma (HPC)-like (1 [2%]). Island and nested patterns had not previously been described. The diagnosis of myxoid liposarcoma was confirmed by fluorescence in situ hybridization studies for DDIT3 (also known as CHOP) rearrangement. The morphologic spectrum of myxoid liposarcoma spans well beyond its typical appearance of spindle cells in a myxoid stroma with a prominent vascular pattern. Awareness of the variety of histologic patterns is critical to avoid misdiagnosis, especially in small biopsy specimens.