Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
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淋巴细胞性脉络膜脑膜炎病毒对α/β干扰素和γ干扰素的耐药性
DOI：
10.1128/jvi.68.3.1951-1955.1994
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发表时间：
1994
影响因子：
5.4
通讯作者：
R. Zinkernagel
中科院分区：
文献类型：
--
作者：
D. Moskophidis;Manuel Battegay;M. A. Bruendler;Elisabeth Laine;Ion Gresser;R. Zinkernagel
在 C57BL/6 小鼠和各种细胞系中评估了各种淋巴细胞脉络丛脑膜炎病毒 (LCMV) 株对 α/β 干扰素 (IFN-α/β) 或 γ 干扰素 (IFN-gamma) 的敏感性。体内抗IFN-γ治疗表明，LCMV毒株Armstrong、Aggressive和WE对IFN-γ最敏感，而Traub、Cl 13-Armstrong和Docile具有抗性。在体外观察到对重组 IFN-γ 的相同敏感性模式。体内抗 IFN-α/β 治疗显示 Aggressive、Armstrong 和 WE 的复制显着增加；对于 Docile、Cl 13-Armstrong 或 Traub，效果不太明显。相应地，WE、Armstrong 和 Aggressive 在体外对纯化的 IFN-α/β 均相对敏感，而 Cl 13-Armstrong、Docile 和 Traub 的耐药性更强。总体而言，LCMV 毒株在成年免疫活性小鼠中建立持续感染的能力与其对 IFN-γ 和 IFN-α/β 的相对抵抗力之间存在良好的相关性。
The susceptibility to alpha/beta interferon (IFN-alpha/beta) or to gamma interferon (IFN-gamma) of various lymphocytic choriomeningitis virus (LCMV) strains was evaluated in C57BL/6 mice and in various cell lines. Anti-IFN-gamma treatment in vivo revealed that the LCMV strains Armstrong, Aggressive, and WE were most susceptible to IFN-gamma whereas Traub, Cl 13-Armstrong, and Docile were resistant. The same pattern of susceptibility to recombinant IFN-gamma was observed in vitro. In vivo treatment with anti-IFN-alpha/beta showed a sizeable increase in replication of Aggressive, Armstrong, and WE; effects were less pronounced for Docile, Cl 13-Armstrong, or Traub. Correspondingly, WE, Armstrong, and Aggressive were all relatively sensitive to purified IFN-alpha/beta in vitro, and Cl 13-Armstrong, Docile, and Traub were more resistant. Overall, there was a good correlation between the capacity of LCMV strains to establish a persistent infection in adult immunocompetent mice and their relative resistance to IFN-gamma and IFN-alpha/beta.
绘制单纯疱疹病毒对小鼠干扰素α/β抗性的遗传区域编码图。
DOI：
10.1099/0022-1317-74-11-2325
发表时间：
1993
期刊：
The Journal of general virology
影响因子：
--
作者：
Su,YH;Oakes,JE;Lausch,RN
通讯作者：
Lausch,RN