Molecular population genetics of sex determination genes: the transformer gene of Drosophila melanogaster.
Molecular population genetics of sex determination genes: the transformer gene of Drosophila melanogaster.
复制标题
性别决定基因的分子群体遗传学：果蝇的转化基因。
DOI：
10.1093/genetics/136.4.1367
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发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
Schaeffer,SW
中科院分区：
文献类型：
--
作者：
Walthour,CS;Schaeffer,SW
The transformer locus (tra) produces an RNA processing protein that alternatively splices the doublesex pre-mRNA in the sex determination hierarchy of Drosophila melanogaster. Comparisons of the tra coding region among Drosophila species have revealed an unusually high degree of divergence in synonymous and nonsynonymous sites. In this study, we tested the hypothesis that the tra gene will be polymorphic in synonymous and nonsynonymous sites within species by investigating nucleotide sequence variation in eleven tra alleles within D. melanogaster. Of the 1063 nucleotides examined, two synonymous sites were polymorphic and no amino acid variation was detected. Three statistical tests were used to detect departures from an equilibrium neutral model. Two tests failed to reject a neutral model of molecular evolution because of low statistical power associated with low levels of genetic variation (Tajima/Fu and Li). The Hudson, Kreitman, and Aguade test rejected a neutral model when the tra region was compared to the 5'-flanking region of alcohol dehydrogenase (Adh). The lack of variability in the tra gene is consistent with a recent selective sweep of a beneficial allele in or near the tra locus.
