Therapeutic strategies for human poxvirus infections: Monkeypox (mpox), smallpox, molluscipox, and orf.

Therapeutic strategies for human poxvirus infections: Monkeypox (mpox), smallpox, molluscipox, and orf.
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人类痘病毒感染的治疗策略:猴痘 (mpox)、天花、软体动物痘和 orf

DOI:
10.1016/j.tmaid.2022.102528
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发表时间:
2023-03
影响因子:
12
通讯作者:
Li, Guangdi
Li, Guangdi
中科院分区:
医学3区
文献类型:
--
作者:
De Clercq, Erik;Jiang, Yike;Li, Guangdi

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针对人痘病毒感染(例如猴痘病毒、天花病毒、传染性软体病病毒、奥夫病毒)的治疗和疫苗开发在很大程度上已被放弃,特别是在1980年根除天花之后。人痘是一种自我限制的疾病,几十年来一直局限于中非和西非。然而,自2022年4月以来,mpox迅速以多国暴发的形式出现,迫切需要有效的抗病毒药物和疫苗来控制mpox。在这里,这篇综述重点介绍了可能的治疗选择(如Tecovirimat、Brincdofovir、cidofovir)和其他策略(如疫苗、静脉注射牛痘免疫球蛋白),以管理世界各地的人痘病毒感染。
Therapeutic and vaccine development for human poxvirus infections (e.g., monkeypox (mpox) virus, variola virus, molluscum contagiosum virus, orf virus) has been largely deserted, especially after the eradication of smallpox by 1980. Human mpox is a self-limited disease confined to Central and West Africa for decades. However, since April 2022, mpox has quickly emerged as a multi-country outbreak, urgently calling for effective antiviral agents and vaccines to control mpox. Here, this review highlights possible therapeutic options (e.g., tecovirimat, brincidofovir, cidofovir) and other strategies (e.g., vaccines, intravenous vaccinia immune globulin) for the management of human poxvirus infections worldwide.
DOI: 10.1016/j.antiviral.2006.11.010
发表时间: 2007-07-01
期刊: ANTIVIRAL RESEARCH
影响因子: 7.6
作者:
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