Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
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精神分裂症患者及其未受影响的一级亲属的纹状体功能障碍
DOI：
10.1016/j.schres.2017.08.043
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发表时间：
2018-05-01
影响因子：
4.5
通讯作者：
Chan, Raymond C. K.
中科院分区：
文献类型：
--
作者：
Li, Zhi;Yan, Chao;Chan, Raymond C. K.
尽管实证研究结果表明，精神分裂症患者及其未受影响的一级亲属在处理金钱激励方面存在缺陷，但尚不清楚是否可以在情感激励方面证明类似的缺陷。 26 名精神分裂症患者和 26 名年龄和性别匹配的健康对照；招募 23 名未受影响的一级亲属和 23 名匹配的健康对照者，在 3-Tesla MRI 扫描仪中完成金钱激励延迟 (MID) 任务和情感激励延迟 (AID) 任务。与健康对照者相比，精神分裂症患者及其未受影响的一级亲属在预期金钱奖励时背侧纹状体活性低下。此外，精神分裂症患者在接受金钱和情感激励时，腹侧纹状体表现出过度活跃。这些发现表明，无论诱因类型如何，纹状体功能紊乱可能出现在精神分裂症患者中以及其未患病的一级亲属发病前。 (C) 2017 Elsevier B.V. 保留所有权利。
Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives. (C) 2017 Elsevier B.V. All rights reserved.