Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine
Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine
复制标题
调整经典热芳构化提供雌激素苯并吖啶
作者：
Koga;R.; Oishi;T.; Torikai;K.
多样性导向的倍增策略，它产生两个12-芳基苯并吖啶从一个单一的三芳基甲醇前体的开发，以构建一个库的候选药物的生物活性化合物的鉴定。对这个12-芳基苯并吖啶库的探索提供了作为雌激素化合物的4′-OH衍生物。
The diversity-oriented doubling strategy, which generates two 12-arylbenzoacridines from a single triarylmethanol precursor was developed to construct a library of drug candidates for the identification of biologically active compounds. Exploration of this 12-arylbenzoacridine library furnished a 4′-OH derivative as an estrogenic compound.