Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.
Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.
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DOI：
10.14797/mdcvj.1294
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发表时间：
2023
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外周动脉疾病（PAD）是一个全球性的健康问题，其患病率上升归因于肥胖、糖尿病、衰老和吸烟等因素。在PAD患者中，慢性肢体威胁缺血（CLTI）是最严重的表现，与大量的发病率和死亡率相关。虽然血管重建术仍然是CLTI的主要治疗方法，但并非所有患者都适合此类干预措施，因此需要其他替代方法。血管生成受损，即新血管的生长受损，是PAD的一个核心特征，尽管几十年的研究，有效的临床治疗仍然难以捉摸。表观遗传学，研究基因表达的可遗传变化，在了解PAD发病机制方面取得了突出的进展。在这里，我们探讨了在PAD背景下表观遗传调控在血管生成中的作用，重点关注长链非编码rna和成纤维细胞内皮细胞转分化。此外，我们还讨论了代谢控制和表观遗传调控之间的相互作用，为改善PAD治疗提供了潜在的新治疗途径。本文旨在简要介绍表观遗传学在血管生成和PAD研究中的应用，以启发这一前景广阔的领域的进一步研究。
Peripheral arterial disease (PAD) represents a global health concern with a rising prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among patients with PAD, chronic limb-threatening ischemia (CLTI) is the most severe manifestation, associated with substantial morbidity and mortality. While revascularization remains the primary therapy for CLTI, not all patients are candidates for such interventions, highlighting the need for alternative approaches. Impaired angiogenesis, the growth of new blood vessels, is a central feature of PAD, and despite decades of research, effective clinical treatments remain elusive. Epigenetics, the study of heritable changes in gene expression, has gained prominence in understanding PAD pathogenesis. Here, we explore the role of epigenetic regulation in angiogenesis within the context of PAD, with a focus on long non-coding RNAs and fibroblast-endothelial cell transdifferentiation. Additionally, we discuss the interplay between metabolic control and epigenetic regulation, providing insights into potential novel therapeutic avenues for improving PAD treatments. This review aims to offer a concise update on the application of epigenetics in angiogenesis and PAD research, inspiring further investigations in this promising field.