The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens
The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens
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DOI：
10.1016/s0091-3057(97)00527-3
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发表时间：
1998-04-01
影响因子：
3.6
通讯作者：
Seppälä, T
中科院分区：
文献类型：
--
作者：
Kankaanpää, A;Meririnne, E;Seppälä, T
用清醒、自由活动大鼠在体微透析技术研究了苯丙胺衍生物对延髓外侧核细胞外5-羟色胺（5-HT）和多巴胺浓度的急性影响。5-羟色胺，多巴胺，和他们的主要代谢产物进行了测定，通过高效液相色谱电化学检测。安非他明（1.0-9.0 mg/kg）显著升高多巴胺水平，但不影响5-HT水平，除了在最高剂量给药。3，4-亚甲二氧基苯丙胺（MDA，1.0-9.0 mg/kg）和3，4-亚甲二氧基甲基苯丙胺（MDMA，1.0-9.0 mg/kg）均能剂量依赖性地升高5-HT和多巴胺水平。2，5-二甲氧基-4-甲基苯丙胺（DOM，0.5-1.0 mg/kg）对5-HT水平无影响，提示细胞外5-HT水平在致幻活性中起次要作用。MDA和MDMA对5-HT水平的强烈影响表明，它们对多巴胺能机制的作用与致幻剂不同。此外，亚甲二氧基苯丙胺可能通过与苯丙胺相似的多巴胺能机制发挥作用。(C)1998年爱思唯尔科学公司
The acute effects of amphetamine derivatives on extracellular concentration of serotonin (5-HT) and dopamine in the nucleus accumbens were studied with in vivo microdialysis using conscious, freely moving rats. 5-HT, dopamine, and their major metabolites were measured by HPLC with electrochemical detection. Amphetamine (1.0-9.0 mg/kg) elevated dopamine levels considerably, but failed to affect the levels of 5-HT, except at the highest dose administered. 3,4-Methylenedioxyamphetamine (MDA, 1.0-9.0 mg/kg) and 3,4-methylenedioxymethamphetamine (MDMA, 1.0-9.0 mg/kg) elevated both 5-HT and dopamine levels dose dependently. The failure of 2,5-dimethoxy-4-methylamphetamine (DOM, 0.5-1.0 mg/kg) to affect the 5-HT levels suggests that extracellular levels of 5-HT play a minor role in hallucinogenic activity. The strong effects of MDA and MDMA on levels of 5-HT indicate that their actions on serotonergic mechanisms are different from those of the hallucinogens. In addition, methylenedioxyamphetamines may act via dopaminergic mechanisms similar to those of amphetamine. (C) 1998 Elsevier Science Inc.